With all of the serious hazards noted above, you might forget about basic safety practices that apply anywhere. For example, USA Today pointed out that automobile accidents are the primary cause of death for Americans in foreign countries - deadlier at a more frequent rate than disease or violence. As such, avoid public transportation on vehicles that don't look up to snuff and exercise the same caution if you rent a car abroad.
USA Today also recommended having emergency supplies in your car if driving in an unfamiliar location, like first-aid supplies, a spare battery or charger for your mobile, food and water, spare tire and gauge and similar items.
At your hotel, exercise caution whenever anyone you don't know is requesting entry to your room. If you hear a knock on the door and someone announcing themselves as room service, call the front desk and confirm that they sent someone up. Finally, make sure that any valuables are kept in the room's safe - or the hotel's own safe, if they offer that service.